VThunter
a database for single-cell screening of virus target cells in animal kingdom
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Crab-eating macaque

Scientific Name: Macaca fascicularis

Taxonomy: Cellular organisms-> Eukaryota-> Opisthokonta-> Metazoa-> Eumetazoa-> Bilateria-> Deuterostomia-> Chordata-> Craniata-> Vertebrata-> Gnathostomata-> Teleostomi-> Euteleostomi-> Sarcopterygii-> Dipnotetrapodomorpha-> Tetrapoda-> Amniota-> Mammalia-> Theria-> Eutheria-> Boreoeutheria-> Euarchontoglires-> Primates-> Haplorrhini-> Simiiformes-> Catarrhini-> Cercopithecoidea-> Cercopithecidae-> Cercopithecinae

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Human immunodeficiency virus 2

Family: Reoviridae

Receptor: CD4

Receptor CD4 information

Summary: This gene encodes the CD4 membrane glycoprotein of T lymphocytes. The CD4 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class II MHC molecules. The CD4 antigen is also a primary receptor for entry of the human immunodeficiency virus through interactions with the HIV Env gp120 subunit. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, granulocytes, as well as in various regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, May 2020] [NCBI]  [Proteinatlas]

Data Source

Data set information

Project Date Technology Tissue Condition Cell PMID/DOI
Vthunter_1027 2019.11 10X Genomics AorticArtery Normal 4383 Link
Vthunter_1028 2019.11 10X Genomics CoronaryArtery Normal 3606 Link
Vthunter_110069 2019.12 MARS-seq TotalBrain Normal 768 Link
Featureplot of receptors

Featureplot of receptors

mRNA expression of CD4 in human tissues   [NCBI]

Expression: Broad expression in spleen (RPKM 82.4), lymph node (RPKM 55.1) and 19 other tissues

Protein expression of CD4 in human tissues   [Proteinatlas]